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October 23, 2025ACS Central ScienceOpen Access

Proteome-Wide Discovery of Degradable Proteins Using Bifunctional Molecules

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Authors

IFInes ForrestLCLouis P. ConwayCGClara Gathmann

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Overview

Chemical proteomic strategy shows downregulation of proteins using small-molecule inhibitors, suggesting new degraders.

Key Points

  • Downregulation of proteins identified using a novel chemical proteomic strategy, indicating multiple mechanisms.
  • Proteome-wide screening uncovered diverse proteins influenced by small-molecule inhibitors in human cells.
  • Employing chemical libraries and proteomic profiling, insights into degradable proteins were expanded, offering new therapeutic paths.
  • Findings support the potential for broader applications of targeted protein degradation in therapeutic contexts.

Cite This Study

Forrest et al. (2025) studied this question.

synapsesocial.com/papers/68f9f86eb2c35e10cc4e3ca6https://doi.org/10.1021/acscentsci.5c01594
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