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October 13, 2025Journal of Pediatric Endocrinology and Metabolism

Management of porphyria-like syndrome in tyrosinemia type 1

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Authors

HBHacer BasanBGBerrak Bilginer GürbüzFGFatih Gürbüz

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Overview

This case reports an acute porphyria-like crisis in a child with tyrosinemia type 1, revealing severe hyponatremia and highlighting the role of fluid management.

Key Points

  • Management with intravenous hemin therapy led to full neurological recovery in a 9-year-old girl.
  • The patient exhibited severe symptomatic hyponatremia and presented with abdominal pain and vomiting.
  • This case marks the first successful treatment of an acute porphyria-like episode in tyrosinemia type 1 in Türkiye.
  • Recognition of SIADH is crucial for effective management in acute neurological crises associated with tyrosinemia type 1.

Cite This Study

Basan et al. (2025) studied this question.

synapsesocial.com/papers/68ed3352c8c3d6f5ff5ddaa4https://doi.org/10.1515/jpem-2025-0311
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