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October 13, 2025

Identification of an M1 Macrophages-Related Signature for Predicting the Survival and Therapeutic Response in Gastric Cancer.

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Authors

YWYue WangHCHaodong CuiKGKai Guo

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Overview

Analysis reveals that an M1 macrophages-related signature predicts therapeutic response in gastric cancer, suggesting tailored treatment approaches.

Key Points

  • The developed six-gene risk signature effectively predicts survival and therapy response in gastric cancer patients.
  • Using TCGA data, a strong correlation was found between M1 macrophages and prognosis, validated by GEO datasets.
  • Immune infiltration analysis indicated that low-risk gastric cancer patients are potentially more responsive to immunotherapy.
  • Fibronectin 1, identified as the hub gene, plays a significant role in gastric cancer cell proliferation and migration.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68ece2abd1bb2827d1297427https://doi.org/10.1049/syb2.70041
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