October 13, 2025Journal of Neuroimmune PharmacologyOpen Access

Differential Effects of Cannabinoid Receptor 2 Agonists on HIV Replication and Inflammatory Activation in Monocyte-Derived Macrophages and Induced Pluripotent Stem Cell-Derived Microglia

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Cannabinoid receptor 2 activation significantly reduces HIV replication in both macrophages and microglia, highlighting its potential for therapeutic use.
Primary human monocyte-derived macrophages showed reduced cytokine release upon activation with the synthetic agonist JWH-133, in contrast to microglia.
RNA sequencing indicated that cannabinoid receptor 2 agonism primarily affected immune response pathways in macrophages while influencing homeostatic functions in microglia.
Inflammasome activation was reduced in induced pluripotent stem cell-derived microglia but did not inhibit nuclear factor kB activation during HIV infection.

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Implication

This research demonstrates cannabinoid receptor 2 activation alters HIV replication and inflammation in macrophages and microglia, suggesting therapeutic potential.

Cite This Study

Starr et al. (2025) studied this question.

synapsesocial.com/papers/68ec51df42911f61ef8b2117 https://doi.org/10.1007/s11481-025-10254-x

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Implication

This research demonstrates cannabinoid receptor 2 activation alters HIV replication and inflammation in macrophages and microglia, suggesting therapeutic potential.

Differential Effects of Cannabinoid Receptor 2 Agonists on HIV Replication and Inflammatory Activation in Monocyte-Derived Macrophages and Induced Pluripotent Stem Cell-Derived Microglia

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Discussion

Implication

Cite This Study

Differential Effects of Cannabinoid Receptor 2 Agonists on HIV Replication and Inflammatory Activation in Monocyte-Derived Macrophages and Induced Pluripotent Stem Cell-Derived Microglia

Key Points

Discussion

Implication

Cite This Study