Progressive Hippocampal Neuroarchitecture Changes in the 5×FAD Alzheimer’s Disease Mouse Model

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Discussion

Observational analysis shows behavioral impairments in 5×FAD mice, suggesting links to neuroinflammation and structural plasticity.

Progressive impairments in fine motor coordination and working memory were observed in 5×FAD mice.
Significant age-related reductions in dendritic complexity were noted, including fiber crossing counts and total dendritic length.
Increased accumulation of amyloid β and phosphorylated tau correlated with synaptic protein decline as aging progressed.
The findings indicate disrupted synaptic transmission linked to neuroinflammation in the 5×FAD model.

Jang et al. (2025) studied this question.

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