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October 12, 2025Open Access

TET CpG sequence context specific DNA demeth-ylation shapes progression of IDH-mutant gliomas

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Authors

YHYouri HoogstrateSGSantoesha A. GhisaiLHLevi van Hijfte

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Overview

Observational analysis shows tumor progression in IDH-mutant gliomas impacts DNA methylation, suggesting new prognostic grading methods.

Key Points

  • Increased DNA demethylation correlates with tumor progression in IDH-mutant gliomas, highlighting its role in tumor biology.
  • The newly developed continuous grading coefficient captures changes in DNA methylation more accurately than WHO grading.
  • Analysis of 302 primary and recurrent oligodendrogliomas revealed a continuum of DNA methylation changes linked to aggressiveness.
  • Findings indicate that IDH-mutant gliomas share an epigenetic axis with astrocytomas, indicating broader implications for treatment.

Cite This Study

Hoogstrate et al. (2025) studied this question.

synapsesocial.com/papers/68ebffcfdef9fcb308ff233ehttps://doi.org/10.1101/2025.10.09.681314
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