October 12, 2025Cancer Research

Distinct cellular and molecular patterns in pre-treatment peripheral blood are associated with CAR-T cell outcomes in diffuse large B-cell lymphoma

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Single-cell RNA-sequencing identifies immune features linked to CAR-T response in diffuse large B-cell lymphoma, highlighting clinical implications.

Responders to CAR-T therapy exhibited elevated CD16+ monocytes and CD4+ effector memory T cells, indicating immune readiness.
Non-responders demonstrated inflammation-driven gene expression, particularly upregulating TNF-α response pathways related to resistance.
The presence of B cells was strongly associated with better treatment responses, suggesting their role in therapy effectiveness.
Findings provide insights into the immune landscape and inform future CAR-T therapy development and patient selection.

Gurevich‐Shapiro et al. (2025) studied this question.

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October 12, 2025Cancer Research

View Full Paper

Ask AI

Bookmark

Authors

Single-cell RNA-sequencing identifies immune features linked to CAR-T response in diffuse large B-cell lymphoma, highlighting clinical implications.

Responders to CAR-T therapy exhibited elevated CD16+ monocytes and CD4+ effector memory T cells, indicating immune readiness.
Non-responders demonstrated inflammation-driven gene expression, particularly upregulating TNF-α response pathways related to resistance.
The presence of B cells was strongly associated with better treatment responses, suggesting their role in therapy effectiveness.
Findings provide insights into the immune landscape and inform future CAR-T therapy development and patient selection.

Gurevich‐Shapiro et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark