October 12, 2025Open Access

Integrative Proteome- and Phenome-Wide Assessment Uncovers Causal Protein Drivers and Drug Targets for Heterogeneous Kidney Diseases

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Integrative assessment uncovers 93 proteins significantly linked to kidney outcomes, highlighting their potential as drug targets.
Proteome-wide Mendelian randomization assesses 2,807 circulating proteins among 464,631 participants to identify causal relationships.
The framework distinguishes between renal and extra-renal associations through phenome-wide association studies of 1,020 traits.
Mapping proteins to nine kidney disease subtypes facilitates targeted therapy development, benefiting diverse patient populations.

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Analysis reveals protein drivers and drug targets in chronic kidney disease, indicating subtype-specific effects and systemic implications.

Triozzi et al. (2025) studied this question.

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Analysis reveals protein drivers and drug targets in chronic kidney disease, indicating subtype-specific effects and systemic implications.