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October 12, 2025DNAOpen Access

Genomic, Epigenomic, and Immuno-Genomic Regulations of Vitamin D Supplementation in Multiple Sclerosis: A Literature Review and in Silico Meta-Analysis

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Authors

PMP. ModakPBPritha BhattacharjeeKGKrishnendu Ghosh

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Overview

Literature review assesses genomic and epigenomic factors in MS, suggesting vitamin D's promise.

Key Points

  • Vitamin D supplementation shows potential to normalize oligodendrocyte activity and improve multiple sclerosis.
  • Evidence indicates that vitamin D deficiency relates to immune dysregulation, linked to aberrant genomic and epigenomic processes.
  • This systematic review analyzes transcriptome and methylome profiling, identifying significant genetic biomarkers for personalized therapy.
  • Integration of clinical evidence with in silico methods provides insights into therapeutic strategy using vitamin D in autoimmune disorders.

Cite This Study

Modak et al. (2025) studied this question.

synapsesocial.com/papers/68ebe3d6becc64ad52fdac6ahttps://doi.org/10.3390/dna5040048
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of vitamin D as adjuvant therapy on multiple sclerosis: an updated systematic review and meta-analysis of randomized controlled trials2025
  2. 2Structure based in silico screening of natural Vitamin D analogs for targeted and safer treatment of resistant multiple sclerosis2025 · 3 citations
  3. 3Epstein–Barr Virus, Lower Vitamin D, Low Sun Exposure, and <i><scp>HLA</scp>‐<scp>DRB1</scp>*1501</i> Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset2025 · 8 citations
  4. 4Vitamin <scp>D3</scp> Supplementation Modulates Inflammatory Protein <scp>CHI3L1</scp> / <scp>YKL</scp> ‐40 and Oxidative Stress Status in Multiple Sclerosis2025
  5. 5Epstein-Barr virus infection and vitamin D deficiency are both “causal” for multiple sclerosis (MS) - could the common denominator be their effects on hepcidin levels?2025 · 2 citations