Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 12, 2025Open Access

Overexpression of Proteins Involved in Mitotic Progression Underlies High Proliferation and Chromosomal Instability in Androgen Receptor-Low Triple-Negative Breast Cancer

View Full Paper
Ask AI
Bookmark
Share

Authors

PRPadmashree C.G. RidaRARaphael AndreaeNBNoah Bikhazi

Discussion

Loading...

Member takes

Overview

This review reveals how high proliferation and chromosomal instability manifest in AR-low TNBC, suggesting key molecular targets for therapy.

Key Points

  • AR-low TNBC shows rapid proliferation alongside chromosomal instability, which drives tumor evolution and treatment resistance.
  • The research highlights a FoxM1–WDR5–ASPM axis that promotes mitotic dysregulation, enhancing tumor growth and intra-tumoral diversity.
  • TP53 mutations exacerbate the dysregulated network, allowing aneuploid cells to survive, thus impacting cancer progression and treatment response.
  • Understanding these pathways may reveal actionable therapeutic strategies to combat high proliferation in genomically unstable cancers.

Cite This Study

Rida et al. (2025) studied this question.

synapsesocial.com/papers/68ebc91af2c3e4d8d926e33fhttps://doi.org/10.20944/preprints202510.0602.v1
View Full Paper
Ask AI
Bookmark
Share