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October 12, 2025Case Reports in DentistryOpen Access

Nonsurgical Retreatment of a 16 × 9 mm Osteolytic Lesion With Buccal Bone Regeneration Using a Bioceramic Sealer: A Clinical and NGS‐Based Microbiological Case Report With 30‐Month Follow‐Up

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Authors

ASAndrea SpinelliFDFrancesco d’ErricoABAlessio Buonavoglia

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Overview

Case report reveals complete resolution of osteolytic lesions in adult patient, indicating microbiological assessment's role in treatment planning.

Key Points

  • Complete resolution of a large osteolytic lesion was achieved following nonsurgical endodontic retreatment.
  • Next-generation sequencing revealed distinct bacterial profiles in the affected teeth, aiding treatment decision-making.
  • Combining manual, rotary, and reciprocating protocols with a bioceramic sealer effectively managed the extensive lesion.
  • Progressive healing was confirmed through radiographic assessments over a 30-month follow-up period.

Cite This Study

Spinelli et al. (2025) studied this question.

synapsesocial.com/papers/68ebabe3155248a327effc2ehttps://doi.org/10.1155/crid/9703223
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluation of the Retreatability and Different Supplementary Cleaning Techniques for Removing Bioceramic Sealers in Oval-Shaped Canals.2025
  2. 2NONSURGICAL SINGLE-VISIT ENDODONTIC TREATMENT APPROACH TO PERIAPICAL LESIONS: CASE SERIES2025
  3. 3Non-surgical endodontic management of calcific metamorphosis with periapical lesion using bioactive glass: a case report2025
  4. 4Apexification of a traumatic central incisor with bioceramic putty: A case report2025
  5. 5Regenerative Endodontic Procedure of a Mature Anterior Tooth With Open Apex and Chronic Apical Abscess: A Case Report With 4‐Years Follow‐Up2025 · 2 citations