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October 11, 2025Drug Discovery TodayOpen Access

Therapeutic strategies targeting ocular vasculopathies: Current advances and emerging challenges

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Authors

JDJulie Le DuCRCyril Ronco

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Overview

This review discusses anti-VEGF therapies and emerging treatments for ocular vasculopathies, suggesting future directions.

Key Points

  • Anti-VEGF therapies significantly improved outcomes in ocular vasculopathies but face challenges including variable response and resistance.
  • Emerging strategies involve targeting pathways like PDGF and Ang-2 to enhance treatment efficacy and overcome established limitations.
  • Innovations such as gene therapy and long-acting biologics are promising for sustained treatment while reducing frequent injections.
  • Exploring complementary approaches targeting inflammation and neuroprotection may help preserve retinal function and optimize therapy.

Cite This Study

Du et al. (2025) studied this question.

synapsesocial.com/papers/68ea72339f1bd4df558cedfehttps://doi.org/10.1016/j.drudis.2025.104496
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