Multiple pregnancy with complete hydatidiform mole and coexisting normal fetus: systematic review and meta‐analysis of clinical outcomes from non‐randomized studies

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Discussion

Systematic review reports high maternal risks and complications in pregnancies with complete hydatidiform mole.

Pregnancies with CHMCF show a high risk of maternal complications, including pre-eclampsia and postpartum hemorrhage.
Preterm birth occurred in 67.8% of cases, indicating significant obstetric risks related to CHMCF.
The pooled proportion of live births was 46.5%, with many delivered by Cesarean section due to complications.
Overall, screening and early intervention are crucial, as the risk for gestational trophoblastic neoplasia remains notable.

Salmeri et al. (2025) studied this question.

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