October 11, 2025

LAMA3 Orchestrates Immune Evasion and Metabolic Reprogramming in Pancreatic Ductal Adenocarcinoma: Insights from Multi-Omics Integration

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High expression of LAMA3 in pancreatic ductal adenocarcinoma correlates with immune evasion and tumor progression.
LAMA3 upregulation was associated with pathways in cell adhesion and immune regulation, indicating its significance in PDAC.
Analysis combining various omics techniques revealed distinct regulatory networks involving LAMA3 and its upstream regulator EP300.
Integration of single-cell and bulk transcriptomics highlighted LAMA3's role in tumor evolution and potential therapeutic targeting.

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Integrative analysis reveals LAMA3 influences immune evasion and metabolic reprogramming in PDAC.

Li et al. (2025) studied this question.

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