October 11, 2025

Profound neonatal encephalopathy in a neonate with iatrogenic hypermagnesemia

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Severe hypermagnesemia led to profound neonatal encephalopathy, requiring interventions including fluid resuscitation.
After treatment for hypermagnesemia, the infant's neurological exam improved significantly by day 7 of life.
Root cause analysis identified total parenteral nutrition as the source of the dangerous hypermagnesemia.
Highlighting timely recognition of systemic toxicity can prevent further neurological damage in preterm infants.

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This case reveals the impact of hypermagnesemia on neurological outcomes in preterm infants, highlighting systemic toxicity complications.

Lo et al. (2025) studied this question.

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This case reveals the impact of hypermagnesemia on neurological outcomes in preterm infants, highlighting systemic toxicity complications.