This study demonstrates how acidifying agents alter pharmacokinetic parameters of erlotinib and gefitinib in Wistar rats, suggesting careful monitoring of drug interactions.
Key Points
Both erlotinib and gefitinib pharmacokinetic parameters were significantly altered by acidifying agents.
High doses of citric acid increased the Cmax of erlotinib by 103% and the area under the curve by 35%.
Significant liver enzyme elevations were observed in rats after two weeks of consuming acidifying agents.
Close monitoring is necessary when administering erlotinib and gefitinib with acidifying agents, given their impact on drug kinetics.