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October 10, 2025Annals of HematologyOpen Access

“B” symptoms and CBV conditioning negatively impact survival in mantle cell lymphoma patients undergoing autologous stem cell transplantation

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Authors

KCKarolina ChromikMedical University of SilesiaAWAgata Wieczorkiewicz-KabutMedical University of SilesiaPZPatrycja ZielińskaMedical University of Silesia

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Implication

Retrospective analysis evaluates the influence of B symptoms and CBV conditioning on survival in MCL patients undergoing autologous stem cell transplantation, suggesting need for adaptive treatment strategies.

Key Points

  • The presence of B symptoms is linked to poorer overall survival in mantle cell lymphoma patients undergoing ASCT.
  • CBV conditioning was associated with inferior progression-free survival compared to BeEAM conditioning.
  • At 3 and 5 years, overall survival rates were 78.3% and 75.2%, respectively, showing the effectiveness of ASCT.
  • Post-transplant complications occurred in 64% of patients, highlighting the need for improved management strategies.

Cite This Study

Chromik et al. (2025) studied this question.

synapsesocial.com/papers/68e9435d2d5336d28fb28a04https://doi.org/10.1007/s00277-025-06666-7
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