October 10, 2025Frontiers in PharmacologyOpen Access

Protective effects of avenanthramide-C against cisplatin-induced cardiotoxicity in rats by attenuating oxidative stress, inflammatory cytokines, and modulating p62–Keap1–Nrf2 pathway

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Discussion

Observational analysis finds reduced oxidative stress and inflammatory cytokines in Wistar rats, suggesting avenanthramide-C aids cardiac protection.

Avenanthramide-C treatment significantly reduced markers of oxidative stress and inflammation in rat hearts.
Increased levels of protective markers p62, Nrf2, and superoxide dismutase were observed with avenanthramide-C administration.
Cisplatin treatment elevated levels of cardiac injury indicators, while avenanthramide-C mitigated these adverse effects.
The findings highlight avenanthramide-C as a potential therapeutic agent against cardiotoxicity associated with cisplatin treatment.

Maha A. Aldubayan (2025) studied this question.

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Observational analysis finds reduced oxidative stress and inflammatory cytokines in Wistar rats, suggesting avenanthramide-C aids cardiac protection.