October 10, 2025Food FrontiersOpen Access

Engineering Gossypol‐Free Cottonseeds for Future Global Food Security and Agricultural Sustainability

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The development of ultralow gossypol cottonseed could ease protein malnutrition for over 500 million people globally, enhancing food security.
Utilizing CRISPR/Cas9 and RNA interference methods, researchers successfully reduced toxic gossypol levels while preserving plant defense features.
This approach positions cotton as a dual-purpose crop, providing valuable fiber and safe, high-quality protein for diverse food systems.
Future advancements in genomic selection and precision breeding are crucial for further improving cottonseed's nutritional value and sustainability.

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Biotechnology demonstrates reduced gossypol in cottonseed, suggesting potential for improved food security and agricultural sustainability.

Mehari et al. (2025) studied this question.

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Biotechnology demonstrates reduced gossypol in cottonseed, suggesting potential for improved food security and agricultural sustainability.