October 9, 2025Circulation Research

Abstract NBT201: Genetically Barcoded Multiplex Single Cell Analysis of Variants in Congenital Heart Disease

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FXFeng Xiao TTTran Thanh Thu HLHe Li

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Implication

This analysis identifies functional roles of genetic variants in congenital heart disease, suggesting broader implications for understanding cardiovascular genetics.

Key Points

The developed platform assesses variants of unknown significance in congenital heart disease, showing potential pathogenic effects.
Using genetically barcoded iPSCs, the study analyzed 16 lines, revealing altered cardiac differentiation in specific variants.
This method combines genome editing and RNA-seq, making it scalable for investigating genetic contributions to diseases.
Findings suggest that certain non-coding genetic variants impact cardiac differentiation, indicating their relevance in CHD.

Cite This Study

Xiao et al. (2025) studied this question.

synapsesocial.com/papers/68e80eb363e2e2f707877dfb https://doi.org/10.1161/res.137.suppl_1.nbt201

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Implication

This analysis identifies functional roles of genetic variants in congenital heart disease, suggesting broader implications for understanding cardiovascular genetics.

Abstract NBT201: Genetically Barcoded Multiplex Single Cell Analysis of Variants in Congenital Heart Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Abstract NBT201: Genetically Barcoded Multiplex Single Cell Analysis of Variants in Congenital Heart Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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