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October 9, 2025Circulation Research

Abstract Thu164: Sexual Dimorphism In the Cardiac Response To Methamphetamines

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Authors

ADApril L. DarrowUniversity of Hawaiʻi at MānoaRSRalph V. ShohetUniversity of Hawaiʻi at Mānoa

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Implication

Observation reveals reduced cardiac function in ovariectomized females and delayed DCM onset in orchidectomized males.

Key Points

  • Methamphetamine impairs cardiac function and survival in male mice compared to females, leading to dilated cardiomyopathy.
  • Ovariectomized female mice exhibit reduced ejection fraction and increased left ventricular diameter following meth treatment.
  • Orchidectomized males develop dilated cardiomyopathy more slowly than untreated males with meth exposure over five months.
  • Estrogen appears to protect against methamphetamine's cardiotoxic effects, suggesting hormonal influences on cardiac pathology.

Cite This Study

Darrow et al. (2025) studied this question.

synapsesocial.com/papers/68e80eb363e2e2f707877dafhttps://doi.org/10.1161/res.137.suppl_1.thu164
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