October 9, 2025Circulation Research

Abstract Fri143: Constitutive Expression of Cardiomyocyte Klf9 Precipitates Metabolic Dysfunction and Spontaneous Heart Failure

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Authors

CTChandni ThakkarRutgers, The State University of New Jersey SASaleena AlikunjuUniversity of Miami AVAishwarya VenkatasubramanianRutgers, The State University of New Jersey

Discussion

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Implication

Conditional expression of Klf9 causes significant metabolic disruption and heart failure in mice, suggesting transcriptional dysregulation impacts cardiac health.

Key Points

Klf9KI mice develop spontaneous heart failure indicated by a poor ejection fraction of 24% at 8 weeks, leading to early mortality.
Transcriptome analysis reveals significant changes in gene expression, particularly in metabolic genes, with 949 genes dysregulated by 4 weeks.
Mitochondrial function declines significantly by 4 weeks, correlating with a 3.5-fold increase in reactive oxygen species production.
Constitutive Klf9 expression disrupts metabolic homeostasis, highlighting its role in cardiac hypertrophy and dysfunction.

Cite This Study

Thakkar et al. (2025) studied this question.

synapsesocial.com/papers/68e80eb363e2e2f707877d74 https://doi.org/10.1161/res.137.suppl_1.fri143

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Implication

Conditional expression of Klf9 causes significant metabolic disruption and heart failure in mice, suggesting transcriptional dysregulation impacts cardiac health.