Abstract Fri021: Local Controlled Release of an Optimized Angiogenic Growth Factor Cocktail Improves Regeneration in Ischemic Injury

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The VIP-loaded biomaterial increased perfused vascular density by 6-fold compared to the blank control at one week.
Using a rat model of ischemic wound healing, enhanced vascularization improved both the rate and magnitude of wound closure.
An iterative design approach identified top angiogenic factors, VEGF, IGF-1, and PDGF, for optimal controlled release.
This research highlights the potential of proangiogenic therapies to drive regeneration in compromised microcirculatory networks.

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Controlled release of a proangiogenic factor cocktail enhances vascularization in ischemic injury, suggesting new regenerative therapies.

Roser et al. (2025) studied this question.

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