October 9, 2025Frontiers in ImmunologyOpen Access

Pannexin-1 hemichannels promote experimental colitis inflammation in a CD4+ T cell-specific manner

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Pannexin-1 is crucial for developing colitis through its role in CD4+ T cells, enhancing inflammation.
Elevated Pannexin-1 levels were observed in ulcerative colitis patients, linking it to inflammation development.
Effector CD4+ T cells convert into pathogenic Th2-like cells due to Pannexin-1, contributing to neutrophil accumulation.
The Pannexin-1 pathway suggests potential therapeutic targets for managing colitis-related inflammation.

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Experimental findings reveal Pannexin-1's role in promoting Th2-like responses in colitis, suggesting implications for treatment.

Mina et al. (2025) studied this question.

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