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October 9, 2025Alzheimer s & DementiaOpen Access

Effect modifiers of the MIND diet for cognition in older adults: The MIND diet trial

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Authors

SHShannon HallowayNANeelum T. AggarwalKAKonstantinos Arfanakis

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Overview

Randomized trial observed BMI as a significant effect modifier of the MIND diet on cognition, suggesting benefits for individuals with obesity.

Key Points

  • Cognitive scores improved for individuals with obesity following the MIND diet, indicating potential cognitive benefits.
  • In participants with BMI ≥ 35 kg/m², the MIND diet was linked to a higher global cognition score change of 0.040 units per year.
  • The analysis utilized a linear mixed-effects model to evaluate how participant characteristics influenced cognitive outcomes.
  • The findings highlight the importance of considering BMI as an effect modifier when assessing dietary impacts on cognition.

Cite This Study

Halloway et al. (2025) studied this question.

synapsesocial.com/papers/68e79cf2ed88661f66c2e06fhttps://doi.org/10.1002/alz.70731
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The association between the MIND diet and cognitive health in middle-aged and older adults: A systematic review2025
  2. 2MIND Diet, Circulating Inflammatory Biomarkers, and Cognitive Function: A Prospective Study.2025
  3. 3Associations of the MIND Diet with Human Health Outcomes: A Scoping Review2025 · 7 citations
  4. 4The association between the MIND-NL diet, Dutch dietary guidelines, and global cognitive function in an older population at risk for cognitive decline2025
  5. 5MIND Diet and Hippocampal Sclerosis Among Community-Based Older Adults2025