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October 9, 2025Circulation Research

Abstract Fri110: Renal Tubular Mitochondrial AKT1 Improves Cardiac Function in Cardiovascular-Kidney-Metabolic Syndrome

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Authors

HLHugo You‐Hsien LinKCKai‐Ting Chang

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Overview

Transgenic enhancement of renal mitochondrial akt1 improved cardiac outcomes in CKM syndrome, suggesting therapeutic potential.

Key Points

  • Improved cardiac function was observed in mice with enhanced renal mitochondrial akt1, indicating a potential treatment avenue.
  • Cardiac metrics included raised ejection fraction to 73.6% from 66.4% and reduced left ventricular wall thickness, strengthening the findings.
  • The intervention led to decreased metabolic dysfunction markers, such as reduced fasting glucose and improved insulin sensitivity, signaling health benefits.
  • Utilizing transgenic mice, the study highlights potential renal protective strategies for treating cardiovascular-kidney-metabolic syndrome.

Cite This Study

Lin et al. (2025) studied this question.

synapsesocial.com/papers/68e77f09d1c187e1c108fbc7https://doi.org/10.1161/res.137.suppl_1.fri110
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