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October 9, 2025Circulation Research

Abstract Thu134: Inherited Variant in MRC2 Causes Cardiac Fibroblast Dysfunction and Increases Atrial Fibrillation Susceptibility

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Authors

KHKevin HoJKJoshua A. KeefeSJSung Yun Jung

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Overview

Study reveals the E990G MRC2 variant increases atrial fibrillation risk by altering cardiac fibroblast function.

Key Points

  • E990G-het mice showed increased atrial fibrillation susceptibility at 60%, compared to 20% in controls.
  • Collagen deposition in ACFs from E990G-het mice was significantly greater than that of wild-type controls.
  • Differential expression of fibrotic regulators was found in E990G-het versus wild-type mice.
  • MRC2 E990G variant may create an atrial fibrillation-prone substrate through matrix remodeling.

Cite This Study

Ho et al. (2025) studied this question.

synapsesocial.com/papers/68e77f09d1c187e1c108fb76https://doi.org/10.1161/res.137.suppl_1.thu134
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