October 9, 2025Circulation Research

Abstract Wed146: Generation and characterization of induced pluripotent stem cell-derived cardiomyocytes from uncontrolled diabetic patients with ischemic and non-ischemic cardiomyopathy

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Authors

SCSung Woo ChoNational Institutes of Health HKHyoung Kyu KimInje University JHJin HanState Administration of Traditional Chinese Medicine of the People's Republic of China

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Implication

This analysis reveals altered electrophysiological properties in iPSC-CMs from diabetic patients, suggesting new modeling avenues for cardiac conditions.

Key Points

Action potentials from iPSC-CMs showed significant differences, indicating altered electrical properties in diabetes patients.
RNA sequencing highlighted gene expression changes related to fibrosis and inflammation in diabetic cardiomyopathy.
Ischemic and non-ischemic patients both exhibited distinct cardiac cellular characteristics compared to controls.
These findings suggest iPSC-CMs could advance research in diabetic heart disease and drug discovery.

Cite This Study

Cho et al. (2025) studied this question.

synapsesocial.com/papers/68e77f09d1c187e1c108fb6e https://doi.org/10.1161/res.137.suppl_1.wed146

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Implication

This analysis reveals altered electrophysiological properties in iPSC-CMs from diabetic patients, suggesting new modeling avenues for cardiac conditions.

Abstract Wed146: Generation and characterization of induced pluripotent stem cell-derived cardiomyocytes from uncontrolled diabetic patients with ischemic and non-ischemic cardiomyopathy

Discussion

Member takes

Implication

Key Points

Cite This Study

Abstract Wed146: Generation and characterization of induced pluripotent stem cell-derived cardiomyocytes from uncontrolled diabetic patients with ischemic and non-ischemic cardiomyopathy

Discussion

Member takes

Implication

Key Points

Cite This Study

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