Impact of Direct Oral Anticoagulant Uptake on Hospitalizations for Stroke/Transient Ischemic Attack, Intracranial Hemorrhage, and Gastrointestinal Bleeding in Individuals With Atrial Fibrillation: A Population‐Based Study
Population-based study shows reduced hospitalization for intracranial hemorrhage and costs, suggesting benefits of DOACs.
Key Points
DOAC uptake correlated with a 12% reduction in intracranial hemorrhage rates and a 26% cost decrease for patients with atrial fibrillation.
Hospitalization rates for gastrointestinal bleeding initially increased but declined over time, indicating a complicated risk pattern with DOAC use.
Analysis included data from over 12,000 hospitalizations for intracranial hemorrhage and nearly 60,000 for gastrointestinal bleeding observed between 2003 and 2021.
Findings emphasize the potential economic benefits of DOACs despite stable rates of stroke, supporting their real-world effectiveness.