Design, Synthesis, Molecular Docking, ADME‐T and In Vitro Anticancer Assessment of Phenyl‐Substituted‐Pyrimidin‐Benzenesulfonamide Derivatives as Potential BRAFV600E/WT Inhibitors

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This study evaluates new compounds targeting braf v600e in melanoma, indicating strong anticancer potential.

All derivatives show stronger affinity for braf v600e over wild-type braf, enhancing treatment options.
Ten phenyl-substituted derivatives were synthesized, demonstrating significant in vitro cytotoxic activities.
The study utilized molecular docking and evaluated adme-t properties to predict drug behavior.
Findings support the synthesized compounds, particularly VA03, as promising candidates for melanoma treatment.

Singh et al. (2025) studied this question.

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View Full Paper

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This study evaluates new compounds targeting braf v600e in melanoma, indicating strong anticancer potential.

All derivatives show stronger affinity for braf v600e over wild-type braf, enhancing treatment options.
Ten phenyl-substituted derivatives were synthesized, demonstrating significant in vitro cytotoxic activities.
The study utilized molecular docking and evaluated adme-t properties to predict drug behavior.
Findings support the synthesized compounds, particularly VA03, as promising candidates for melanoma treatment.

Singh et al. (2025) studied this question.

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