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October 9, 2025AntibioticsOpen Access

Effect of Meropenem, Sulbactam, and Colistin Combinations on Resistance Gene Expression in Multidrug-Resistant A. baumannii Clinical Isolates from Panama

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Authors

JPJ PJQJordi Querol‐AudíATAriel Magallón Tejada

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Overview

In vitro analysis reveals how colistin, meropenem, and sulbactam interactions affect gene expression in multidrug-resistant A. baumannii strains.

Key Points

  • Synergistic effects of colistin-meropenem were observed in all tested A. baumannii strains, enhancing treatment efficacy.
  • Colistin, meropenem, and sulbactam combinations influenced the expression of resistance genes, with notable reductions in blaADC and blaOXA-51.
  • Gene expression analysis was performed using quantitative PCR, a key method for assessing antibiotic impact.
  • Findings suggest potential for improved treatment strategies against multidrug-resistant A. baumannii using these antibiotic combinations.

Cite This Study

P et al. (2025) studied this question.

synapsesocial.com/papers/68e70db290569dd607ee61cehttps://doi.org/10.3390/antibiotics14100999
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