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October 9, 2025Open Access

A cognitive behavioral therapy program designed for low-literacy end-users with perinatal depression in Sierra Leone: an investigator- and outcomes assessor-blinded, controlled randomized trial

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Authors

EKEliza KlebanALA. LeeAKAminata Shamit Koroma

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Overview

Randomized controlled trial shows culturally adapted cognitive behavioral therapy improves depression in women, indicating its viability for low-literacy populations.

Key Points

  • Cognitive behavioral therapy significantly reduced perinatal depression symptoms among participants, with effects lasting through nine months postpartum.
  • Median aPHQ9 scores were lower in the cognitive behavioral therapy group compared to control, with a p-value less than 0.001.
  • This study utilized a randomized controlled trial format with trained lay counselors delivering the intervention to enhance accessibility.
  • Results suggest that culturally adapted cognitive behavioral therapy is feasible and effective for improving mental health in low-literacy settings.

Cite This Study

Kleban et al. (2025) studied this question.

synapsesocial.com/papers/68e70da790569dd607ee5a34https://doi.org/10.1101/2025.09.29.25336811
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Perinatal and Childhood Risk Factors of Adverse Early Childhood Developmental Outcomes: A Systematic Review Using a Socioecological Model2025 · 7 citations