Synthesis of benzylamino benzoic acid derivatives showed antibacterial effects and promising anticancer activity, indicating potential therapeutic applications.
Key Points
Several derivatives demonstrate moderate antibacterial activity, with minimum inhibitory concentration ranging from 64 to 128 μg/mL against various bacterial strains.
Compound 18 exhibited anticancer activity with IC50 values of 90.69 μM against Non-Small Cell Lung Cancer and 32.22 μM against Small Cell Lung Cancer.
Crystal structures were confirmed using advanced techniques, including X-ray diffraction, identifying key intermolecular interactions critical for compound stability.
Quantum chemical calculations provided insights into the electronic properties of compounds, contributing to the understanding of their biological activity.