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October 8, 2025PathogensOpen Access

Phage to ESKAPE: Personalizing Therapy for MDR Infections—A Comprehensive Clinical Review

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Authors

AMAndrea MarınoSSStefano StracquadanioFCFederica Cosentino

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Overview

Comprehensive review evaluates phage therapy effectiveness for MDR infections, indicating personalized strategies are essential.

Key Points

  • Phage therapy shows considerable success in treating MDR infections caused by ESKAPE pathogens, with potential to personalize treatments.
  • Evidence from preclinical and clinical cases supports the effectiveness of phage therapy, particularly in salvage therapy for untreatable infections.
  • Challenges like narrow phage host range and bacterial resistance complicate the application of phage therapy for MDR infections.
  • Future advancements in phage therapy require robust clinical trials and standardized manufacturing for establishing efficacy.

Cite This Study

Marıno et al. (2025) studied this question.

synapsesocial.com/papers/68e6bc5f38ca8e474d54a016https://doi.org/10.3390/pathogens14101011
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