Integrating Phytochemical Profiling with Pharmacological Evaluation of Himalayan Mango (Mangifera sylvatica Roxb.) Leaves: GC-MS/MS Insights into Antioxidant, Anti-inflammatory, and Analgesic Potentials
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Key Points
Experiments showed the ethanolic extract of Himalayan mango leaves exhibited notable antioxidant activity with an IC50 value of 348.72 µg/mL.
The extract demonstrated significant anti-inflammatory effects in the protein denaturation assay, comparable to diclofenac with an IC50 value of 142.52 µg/mL.
Mice treated with the extract showed a significant decrease in writhing and paw-licking behavior due to acetic acid and formalin, indicating analgesic effects.
Molecular docking analysis revealed binding affinities indicating potential pharmacological activity of bioactive compounds identified in the extract.