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October 8, 2025Nature CommunicationsOpen Access

Discovery of a CNS active GSK3 degrader using orthogonally reactive linker screening

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Authors

AHAndreas HolmqvistNKNur Mehpare KocatürkCDChristina Duncan

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Overview

This research demonstrates the potential of PROTACs to target GSK3 in CNS diseases, suggesting new treatment avenues.

Key Points

  • GSK3 PROTACs were identified as CNS active, providing new avenues for treating neurodegenerative diseases.
  • Using orthogonally reactive linkers allowed for diverse testing of PROTAC components in cellular assays.
  • The study's findings highlight the role of GSK3 paralogs in disease models, opening doors for further research.
  • This approach may accelerate the discovery of effective chemical probes for various CNS disease concepts.

Cite This Study

Holmqvist et al. (2025) studied this question.

synapsesocial.com/papers/68e6860af44b9035634c2019https://doi.org/10.1038/s41467-025-63928-8
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