Pharmacological Interventions for Agitated Behaviors in Patients with Traumatic Brain Injury: An Updated Systematic Review

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Discussion

Systematic review assesses pharmacological interventions for agitated behaviors in TBI patients, suggesting dexmedetomidine may help.

Insufficient data remains to recommend any medications for managing agitation following TBI, indicating the need for more research.
Of 32 studies evaluated, dexmedetomidine indicated potential benefits, while antipsychotics showed unclear efficacy compared to controls.
In trials, propranolol reduced the intensity of agitation but not its frequency, suggesting it may offer limited benefits.
Current findings highlight inconsistencies in the effectiveness of beta-blockers and valproic acid, warranting further investigation.

Klimenko et al. (2025) studied this question.

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