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October 8, 2025npj Systems Biology and ApplicationsOpen Access

Constraint based modeling of drug induced metabolic changes in a cancer cell line

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Authors

XBXavier BenedictoÅFÅsmund FlobakSINTEFMPMiguel Ponce-de-LeónBarcelona Supercomputing Center

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Implication

Observational analysis reports metabolic alterations from kinase inhibitors in gastric cancer cells, indicating potential therapeutic vulnerabilities.

Key Points

  • Widespread down-regulation of biosynthetic pathways was observed, particularly impacting amino acid metabolism and nucleotide metabolism.
  • Combination treatments showed strong synergistic effects in the PI3Ki–MEKi condition, emphasizing the role of ornithine and polyamine biosynthesis.
  • The study utilized genome-scale metabolic models and transcriptomic profiling to assess drug-induced metabolic changes effectively.
  • Developing the open-source Python package, MTEApy, contributes to reproducibility and broader use of the TIDE frameworks.

Cite This Study

Benedicto et al. (2025) studied this question.

synapsesocial.com/papers/68e6679587ecc93a24d17448https://doi.org/10.1038/s41540-025-00586-y
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