Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 8, 2025JAIDS Journal of Acquired Immune Deficiency SyndromesOpen Access

Characteristics of Individuals with Advanced HIV Disease and Risk Factors for Mortality in a Contemporary Cohort in South Africa

View Full Paper
Ask AI
Bookmark
Share

Authors

JFJoshua FieggenGMGraeme MeintjesABAndrew Boulle

Discussion

Loading...

Member takes

Overview

Retrospective cohort study identifies mortality factors in individuals with advanced HIV disease, highlighting treatment gaps.

Key Points

  • Overall mortality in individuals with advanced HIV disease was reported at 12%, with 6.8% occurring in the first year.
  • Between 19% and 28% of the larger cohort of 72,102 were estimated to have advanced HIV disease during the study period.
  • Cohort included adults with a CD4 count less than 200 cells/mm3, indicating severe immune impairment associated with mortality.
  • Improved adherence to antiretroviral therapy may reduce mortality rates among individuals with advanced HIV disease.

Cite This Study

Fieggen et al. (2025) studied this question.

synapsesocial.com/papers/68e5c1be6950a706b22b57f2https://doi.org/10.1097/qai.0000000000003767
View Full Paper
Ask AI
Bookmark
Share