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October 5, 2025Cancer CellOpen Access

Cell-free DNA fragmentomics in cancer

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Authors

WTWY TsuiPJPeiyong JiangYLY. M. Dennis Lo

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Overview

Review reveals importance of cfDNA fragmentomics in cancer detection, suggesting new opportunities for noninvasive diagnostics.

Key Points

  • cfDNA fragmentomics uncovers specific cellular dysfunctions in cancer, enhancing early detection strategies.
  • Recent clinical trials show promise for fragmentomic analyses in real-world applications, offering noninvasive solutions.
  • Artificial intelligence algorithms enhance the precision of cancer detection by leveraging complex fragmentomic data.
  • Future research will focus on addressing unanswered questions to maximize the potential of liquid biopsies in cancer care.

Cite This Study

Tsui et al. (2025) studied this question.

synapsesocial.com/papers/68e28310dcef4a166ce03cc1https://doi.org/10.1016/j.ccell.2025.09.006
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Circulating Cell-free DNA Fragmentomics Detection and Beyond2025
  2. 2Cell-free DNA fragmentomic characteristics in transposon elements inform molecular regulators and enhance cancer diagnosis2025
  3. 3Circulating tumor cells and tumor-derived cell-free DNA in cancer management: Clinical evidence, limitations, and future directions2026
  4. 4Data from Detection of Brain Cancer Using Genome-wide Cell-free DNA Fragmentomes2025
  5. 5Toward generalizable prediction of cancer signal using a cell-free DNA language model2026