This analysis uncovers kinase activity changes and their link to chronic kidney disease in hyperlipidemic mice, indicating potential therapeutic targets.
Key Points
CKD significantly increases kinase activity in mice, particularly during late-stage disease progression.
Peptide phosphorylation was notably elevated in tyrosine and serine-threonine kinases, implying critical roles in CKD.
Pathway analysis identified major alterations in inflammation, fibrosis, and lipid metabolism pathways linked to kinase changes.
Targeting specific kinases in CKD progression may lead to novel therapeutic strategies addressing cardiovascular complications.
Cite This Study
Bonnin-Marquez et al. (2025) studied this question.