October 3, 2025Clinical ChemistryOpen Access

A-357 Direct establishment of pediatric reference intervals for 16 electrolytes and metabolites on the Roche cobas® pro integrated system in the CALIPER cohort of healthy children

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Discussion

New pediatric reference intervals for 16 electrolytes were established, highlighting CALIPER's significance in enhancing healthcare accuracy.

New pediatric reference intervals were successfully established for 16 electrolytes and metabolites.
Analytical performance was verified, with all assays meeting manufacturer specifications and acceptable patient comparison biases.
The study utilized samples from healthy children across various age groups to create a comprehensive data set.
Age and sex-specific variations were identified for several analytes, emphasizing the need for further neonatal data collection.

Sepiashvili et al. (2025) studied this question.

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New pediatric reference intervals for 16 electrolytes were established, highlighting CALIPER's significance in enhancing healthcare accuracy.