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October 3, 2025International Journal of Molecular SciencesOpen Access

Dietary and Pharmacological Modulation of Aging-Related Metabolic Pathways: Molecular Insights, Clinical Evidence, and a Translational Model

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Authors

AMAntonio Fernando Murillo-CanchoDLDavid Lozano‐PaniaguaBNBruno José Nievas‐Soriano

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Overview

This integrative review highlights the impact of caloric restriction and fasting on aging, suggesting new avenues for intervention.

Key Points

  • Caloric restriction and intermittent fasting improve insulin sensitivity and lipid profiles, enhancing metabolic health.
  • These dietary approaches activate specific molecular pathways like AMP-activated protein kinase and inhibit mTOR signaling.
  • Despite promising results, long-term safety of caloric restriction mimetics like metformin and rapamycin is not yet fully established.
  • The proposed AMAL model integrates personalized diet and digital monitoring to improve adherence and clinical application.

Cite This Study

Murillo-Cancho et al. (2025) studied this question.

synapsesocial.com/papers/68e034fdf0e39f13e7fa358bhttps://doi.org/10.3390/ijms26199643
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  1. 1Geroscience2025 · 31 citations
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  4. 4Impacts of lifestyle change and precise nutrology on healthy longevity: a systematic review2025
  5. 5Pharmacological approaches to anti-age therapy2025