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October 3, 2025Diabetes & Metabolism JournalOpen Access

Association of Remnant Cholesterol Inflammation Index with Cardiovascular Risks and All-Cause Mortality in Individuals with Diabetes or Prediabetes

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Authors

QMQilin MaLDLina DuJPJia Peng

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Overview

Analysis shows remnant cholesterol inflammation index predicts cardiovascular disease and mortality in individuals with diabetes, suggesting early risk identification.

Key Points

  • Higher remnant cholesterol inflammation index quartiles significantly associate with increased all-cause mortality in individuals with diabetes.
  • Analysis revealed an odds ratio of 2.32 for cardiovascular disease risks when comparing the highest to the lowest quartile of the remnant cholesterol inflammation index.
  • Subgroup analyses indicated sex-specific interactions with cardiovascular disease risks while maintaining consistent mortality associations across groups.
  • Findings highlight the combined prognostic impact of remnant cholesterol and inflammation on severe outcomes in those with prediabetes or diabetes.

Cite This Study

Ma et al. (2025) studied this question.

synapsesocial.com/papers/68e034fdf0e39f13e7fa3412https://doi.org/10.4093/dmj.2025.0305
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Predictive Value of Remnant Cholesterol Inflammatory Index for Cardiovascular-Kidney-Metabolic Syndrome Progression: A Prospective Cohort Study2025
  2. 2Dual residual risk of lipid and inflammation: a prospective analysis of RCII on hypertension incidence and cardiovascular prognosis in Chinese and UK populations2026
  3. 3Residual Cholesterol Inflammatory Index: A Predictor of Cardiovascular-Kidney-Metabolic Syndrome; Insights from NHANES and CHARLS Cohorts.2026
  4. 4Association of residual cholesterol-inflammation index with MAFLD and related mortality risk: a population-based study integrating mediation and machine learning analyses2025
  5. 5Association of non-traditional lipid indices with diabetes and insulin resistance in US adults: mediating effects of HOMA-IR and evidence from a national cohort2025 · 10 citations