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October 3, 2025

Impaired IL-10 Receptor Signaling Leads to Inflammation Induced Exhaustion in Hematopoietic Stem Cells

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Authors

WWWilliam Lucas P WadleyHHHelen Q. HuangHLHew Yeng Lai

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Overview

Research reveals IL-10R signaling regulates inflammation-induced exhaustion in hematopoietic stem cells, implying potential therapeutic strategies.

Key Points

  • Impaired IL-10R signaling is critical for maintaining hematopoietic stem cell (HSC) quiescence, especially after inflammation.
  • IL-10R blockade leads to increased cycling of HSCs and accelerates aging symptoms, including functional defects.
  • Jak2V617F mutant HSCs show resistance to aging effects caused by IL-10R blockade, promoting clonal expansion.
  • Findings suggest modulating IL-10R signaling could help preserve HSCs and manage clonal hematopoiesis.

Cite This Study

Wadley et al. (2025) studied this question.

synapsesocial.com/papers/68e034f7f0e39f13e7fa30a5https://doi.org/10.1101/2025.09.30.679613
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