Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 3, 2025Open Access

The Sex-Specific Role of Adrenal Androgens in Youth Psychopathology

View Full Paper
Ask AI
Bookmark
Share

Authors

FWFranka Edith WeisnerBSBianca SerioSVSofie L. Valk

Discussion

Loading...

Member takes

Overview

Longitudinal analysis reveals that salivary DHEA predicts behavior in males but not females, suggesting hormonal influences on youth mental health.

Key Points

  • Higher levels of dehydroepiandrosterone (DHEA) predicted fewer externalizing symptoms in males across follow-ups.
  • Analysis of data from the Adolescent Brain Cognitive Development Study revealed sex-specific hormonal effects on adolescent behavior.
  • No associations were found between DHEA levels and internalizing symptoms in females, highlighting a sex difference in hormonal impact.
  • Adrenarche may represent a crucial hormonal period affecting vulnerability to mental health issues during adolescence.

Cite This Study

Weisner et al. (2025) studied this question.

synapsesocial.com/papers/68e02f46f0e39f13e7fa2ca1https://doi.org/10.1101/2025.09.30.25336972
View Full Paper
Ask AI
Bookmark
Share