This observational analysis found potent aldose reductase inhibition in fenugreek seeds, suggesting potential for managing diabetes complications.
Key Points
Ethanolic seed extracts from Trigonella foenum-graecum show significant aldose reductase inhibitory activity, with the best potency at IC50 = 101.35 μg/mL.
Major phytochemicals identified include saponins at 87.56% and flavonoids at 68.25%, indicating a rich composition in fenugreek seeds.
Fraction B from column chromatography exhibited strong AR inhibition at IC50 = 84.58 μg/mL, comparable to the standard quercetin at 71.23 μg/mL.
Results support fenugreek’s ethnomedicinal usage and highlight the need for further research on its therapeutic applications.