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October 3, 2025Molecular Systems BiologyOpen Access

High-throughput 3D engineered paediatric tumour models for precision medicine

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Authors

MJMoonSun JungVPValentina PoltavetsJSJoanna N. Skhinas

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Overview

This research demonstrates high-throughput drug sensitivity profiling in pediatric tumours, indicating a novel approach for personalized therapy.

Key Points

  • High-throughput drug screening revealed individualized sensitivities in pediatric tumours, enhancing treatment precision.
  • Tumouroids created from patient-derived cells retained genetic and phenotypic characteristics of original cancers, validating the model.
  • The engineering of extracellular matrix hydrogels via 3D bioprinting facilitated successful creation of patient-specific tumour models.
  • This approach may transform preclinical testing and therapeutic strategies for pediatric cancers, addressing current challenges.

Cite This Study

Jung et al. (2025) studied this question.

synapsesocial.com/papers/68e02f46f0e39f13e7fa2bffhttps://doi.org/10.1038/s44320-025-00152-y
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