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October 3, 2025CancersOpen Access

The Tumor Environment in Peritoneal Carcinomatosis and Malignant Pleural Effusions: Implications for Therapy

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Authors

PMPaige O. MirskyPWPatrick L. WagnerMMMaja Mandic-Popov

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Overview

Analysis reveals shared cytokines and T cell suppression in peritoneal carcinomatosis and malignant pleural effusions, indicating new therapeutic potential.

Key Points

  • The tumor environment in peritoneal carcinomatosis promotes aggressive cancer behavior while recruiting and suppressing T cells.
  • Current therapies for peritoneal carcinomatosis and malignant pleural effusions show bleak outcomes, pointing to a need for novel approaches.
  • Cytokines and secretomic components play a critical role in shaping the tumor microenvironment, facilitating treatment resistance.
  • Understanding the interactions within the tumor environment can enhance immunotherapeutic strategies for these severe conditions.

Cite This Study

Mirsky et al. (2025) studied this question.

synapsesocial.com/papers/68e02f3cf0e39f13e7fa2653https://doi.org/10.3390/cancers17193217
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Also Consider

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  1. 1Myelomatous Pleural Effusion Revealing Underlying Plasma Cell Myeloma: An Uncommon Initial Presentation2025
  2. 2The immune microenvironment in endometrial carcinoma: mechanisms and therapeutic targeting2025
  3. 3The Interleukin-8-CXCR1/2 Axis as a Therapeutic Target in Peritoneal Carcinomatosis2025
  4. 4Evaluating the Reliability of Cytological Analysis in Diagnosing Malignant Pleural Effusions: Challenges and Implications2025
  5. 5The role of inflammatory factors in the tumor microenvironment of pancreatic cancer2025