October 3, 2025

Acupuncture in Knee Osteoarthritis: A Narrative Review of Clinical Efficacy and Neuroimmune-Endocrine Mechanisms.

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Narrative review reports acupuncture's pain relief in knee osteoarthritis, suggesting neuroimmune-endocrine mechanisms play a key role.

Acupuncture significantly reduces pain in knee osteoarthritis, enhancing functional outcomes when combined with exercise.
Electroacupuncture notably lowered pain scores compared to sham acupuncture and conventional care, indicating its clinical efficacy.
Mechanistic studies reveal acupuncture modulates neuroimmune-endocrine pathways, influencing pro-inflammatory cytokines and pain processing.
Acupuncture is an effective complementary therapy for knee osteoarthritis, yet optimal techniques and standardization need further research.

Jiao et al. (2025) studied this question.

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